Olaparib is the first drug approved as a PARP inhibitor. The concept is referred to as synthetic lethality. In HRR-deficient tumors, alternative DNA repair by nonhomologous end joining, which is a low fidelity repair mechanism, results in cell death. Double-strand DNA breaks normally would be repaired via homologous recombination repair (HRR), which is a complex process involving many proteins, notably BRCA1 and BRCA2. PARP inhibitors induce the accumulation of single-strand DNA damage and can result in double-strand breaks. PARP has an important role in the repair of single-strand DNA breaks. Poly-ADP ribose polymerase (PARP) is a family of proteins involved in several processes, such as DNA repair, genomic stability, and programmed cell death ( 1). Ovarian cancer is the most lethal gynecologic malignancy worldwide. PARP inhibitors, BRCA wild type, HRD, LOH, genetic counseling Introduction
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